Immune Cell Activation

At a cellular level, psoriasis is the result of a sustained proinflammatory response caused by dysregulation of a complex signaling pathway involving dendritic cells, T-cell activation, and production of proinflammatory cytokines.2-5

Diagram illustrating how psoriasis can affect the skin as well as immune cell activation below the skin.

Look Deeper

Understanding the Impact of Moderate Psoriasis Beyond Skin Involvement

This image illustrates the mechanism of disease and shows the potential burden of moderate psoriasis beyond skin involvement.6

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Interact Deeper

Psoriasis Mechanism of Disease

Check your knowledge about psoriasis here. These questions will provide useful tips about psoriasis to assist you in providing care for your patients.

Question 1

Which of the following is a common feature of psoriasis?1

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Question 2

Name one reason patients with psoriasis may experience systemic inflammation.3

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Question 3

Which of the following is a common comorbidity associated with psoriasis?6

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Question 4

Which process is NOT considered part of the immune-mediated inflammatory response seen in psoriasis?1-2

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Watch Deeper

The Deep Impact of Moderate Psoriasis: Psoriasis, a Systemic Disease

The first chapter in this video series explores the impact of systemic inflammation on patients with moderate psoriasis.


Patients with psoriasis may have other serious comorbidities, including psoriatic arthritis. Healthcare professionals can regularly assess patients with psoriasis for potential signs and symptoms associated with this systemic disease and facilitate multidisciplinary care for appropriate patients.6

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Psoriasis Symptoms and Special Areas

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  1. Menter A, et al. J Am Acad Dermatol. 2019;80(4):1029-1072.

  2. Korman NJ. Br J Dermatol. 2020;182(4):840-848.

  3. Lowes MA, et al. Annu Rev Immunol. 2014;32:227-255.

  4. Benezeder T, et al. Semin Immunopathol. 2019;41(6):633-644.

  5. Nestle FO, et al. N Engl J Med. 2009;361(5):496-509.

  6. Van Voorhees AS, et al. The Psoriasis and Psoriatic Arthritis Pocket Guide: Treatment Algorithms and Management Options. 6th ed. Accessed June 8, 2021.